Joe Donnelly - who won his seat in the conservative state in 2012 thanks, in part, to his opponent Richard Murdoch's outlandish claim that God intends for women to be raped.
Braun defeated IN congressmen Luke Messer and Todd Rokita IN Tuesday's lone statewide primary race with 41 percent of the vote.
"I think it's going to be about a guy who's lived conservatism in the trenches".
And in Ohio, Rep. Jim Renacci cruised to a victory that sets up a run against incumbent Democratic Sen.
"I don't think that the folks from the 3rd District, the most conservative, most Republican congressional district in the State of in are ready for that kind of politics", Shine said.
A Republican legislator from northern IN was defeated IN his bid for what would have been a record-tying 10th four-year term IN the state Senate, while an equally long-serving Democratic senator won his primary.
Rokita and Messer relentlessly attacked Braun for his history of voting in Democratic primaries in a county where the party until recently held a firm grip on local offices.
In recent days, the contest in West Virginia has received the most national attention, with Blankenship portraying himself as a true conservative outsider. It could also be seen as a win for Senate Majority Leader Mitch McConnell, who clashed with Blankenship during the campaign.
Braun beat two other major candidates, Reps.
The elections Tuesday in IN, as well as in North Carolina, Ohio and West Virginia, were the first of 11 primaries slated to take place this month that will be the latest tests of the anti-establishment fervor that helped power Mr. Trump into The White House.
WISH-TV's David Williams said it felt like a party early Tuesday night inside the Brickyard Crossing at the Indianapolis Motor Speedway, where U.S. Rep. Todd Rokita and his supporters gathered to watch election results roll in with excitement. Sherrod Brown, a Democrat who is seeking a third term.
Kyle Kondik, an analyst at the Center for Politics at the University of Virginia, said Messer and Rokita "are going out of their way to be pro-Trump in nearly cartoonish fashion ..."
Mike Braun, a former state representative who spent millions of his own money on the race, led the field with 41 percent of the vote when CNN and NBC called the race shortly after 8 p.m. EST.
Democrats in two in congressional districts say the GOP incumbents - three-term Rep. Jackie Walorski in the 2nd District and Tennessee native and first-term Rep. Trey Hollingsworth in the 9th District - have been absent from the districts and are clueless about what their constituents need.
Lamb has criticized his opponent for relying on the Pence name, which is well-known in the district that Pence's younger brother, Vice President Mike Pence, held for a dozen years before becoming in governor.
Braun was elected to the Indiana State House in 2014.
According to Politico, Braun's effort was powered by almost $6 million of his own money that he either loaned or gave to his campaign.
IN uses an open primary system, meaning that voters are not required to register with a party to vote in a party primary.
In the end, the GOP race was not as close as expected.