De Bruyne has registered a league-best 12 assists for City, while also scoring seven times.
Salah meanwhile has enjoyed a sensational debut season at Liverpool.
The winners will be revealed at the PFA Awards on Sunday, 22nd of April.
The Belgium worldwide was the leading contender heading into the second half of the Premier League season but De Bruyne's form has dipped in recent weeks.
Silva is the only one of the three to taste Premier League glory with City in the past, having been part of the squad which lifted the trophy in 2012 and 2014.
Liverpool superstar Mohamed Salah tops the six man shortlist for this season's Professional Footballers' Association Players' Player of the Year.
The 25-year-old Egyptian forward, arguably the signing of this season, has registered 29 goals across 31 matches; the current record in a 38-game season is 31 and presently co-held by Alan Shearer (1995/96), Cristiano Ronaldo (2007/08) and Luis Suarez (2013/14).
Kane may have gotten plenty of stick from opposition fans for claiming one for the dubious goals this week, but the Spurs frontman has still had a supremely productive season.
The former Chelsea and Fiorentina player is now the Premier League's top scorer, four goals ahead of second-placed Harry Kane.
Harry Kane, Salah's biggest rival for the Premier League Golden Boot, has been nominated after another stellar year for Tottenham.
The Young Player of the Year, which is awarded to the most outstanding player in English football who is 23 or under at the beginning of the season, is equally interesting.