Edwin Encarnacion went deep twice for the Indians, his 29th career multihomer game.
It will be the first start of the season for Clevinger and Ramirez.
If a theme can be deduced from the Mariners first three games, it's that surprises could be in store on a daily basis. The Indians took a 2-0 lead on Encarnacion's leadoff homer in the fourth, which hit the hand-operated scoreboard in left field.
While the Mariners can turn to Daniel Vogelbach to play designated hitter during Cruz's potential absence, they can't realistically expect him to replicate the production the normal starter does on a nightly basis.
The Indians led 2-0 after four innings.
Kyle Schwarber tied it for the visitors in the second with a two-run homer, and the Cubs took a three-run lead in the fifth, but Darvish couldn't hold it.
Cruz, you might recall, was injured in the dugout after hitting a two-run homer Saturday against Cleveland.
Instead, Zunino was spending his second day on the 10-day disabled list with a strained left oblique.
Zunino's wasn't even the most unusual of Mariners injuries in the past week.
In Los Angeles, Dodgers starter Kenta Maeda scattered five hits and a walk, while striking out 10 for the second time in the majors as Los Angeles beat the San Francisco Giants 5-0 for their first win of the season.
GEE, DEE: Maybe that career bio that says Dee Gordon had never played center field before this season was the real April Fool's joke. "I'm seeing the ball good and I want to continue to be that consistent". Who didn't love the side-by-side comparisons of Gordon with Ken Griffey Jr., two home-run swings and bat drops that looked identical, though we know that Gordon's not technically a power hitter.
The one Cactus League game I attended in Peoria, Haniger threw out runners at second and third. Gordon bunted Frietas to third, which is when things got interesting.
In six games with the Braves playing alongside Maui's Kurt Suzuki, Freitas went 4-of-17 with two doubles and two stolen bases.
Leake worked around early trouble and base runners in multiple innings to pitch seven innings and allow two runs on five hits with three walks and four strikeouts.
Haniger is 5-for-8 to start this season.