Victories over Real Madrid and Crystal Palace ahead of the global break have left Mauricio Pochettino's side in a good position in both the Premier League and Champions League as they look to push on from their encouraging finishes to the past two campaigns.
Pochettino had mixed news on the injury front, saying that Toby Alderweireld might be out until January because of a hamstring problem but that Harry Kane, Dele Alli, Harry Winks and Hugo Lloris had returned to training after injury.
They sit in third place in the Premier League and are top of their Champions League group.
But the medical bench isn't quite as jam-packed as it could be as Mousa Dembele and Jan Vertonghen should be fit.
Tottenham have a series of injury doubts ahead of the crucial clash, with a host of big-name players having sat out the worldwide break.
Arsenal face Tottenham on Saturday and Lacazette is expected to feature, with his agent alleviating fears over his standing at the Emirates Stadium.
Petr Cech believes Tottenham must win a trophy to match Arsenal's success, denying suggestions of a north London power shift, reports Sky Sports.
Santi Cazorla is still a long-term injury doubt, and it's not thought Jack Wilshere will make his first Premier League start of the season.
Cech has insisted that finishing above Tottenham this year is not their priority. Only Emmanuel Adebayor (8) and Robert Pires (7) have scored more goals in this fixture in the Premier League.
Tottenham fans have been discussing a "powershift" in the north of the London following last season's league standings.
The game kicks off at the Emirates at 12.30pm on Saturday 18 November.